Generative AI · clinical safety intake

Book-in to medical review.
Sixty seconds.

Intaqe does book-in, triage, case entry and Initial Medical Review against your preloaded RSI — then a simple QC by your CRO or sponsor.

< 60s
Book-in → medical review
60–70%
Lower cost per case
E2B(R3)
Into Argus & Veeva

Pharmacovigilance has processed cases by hand for over 50 years. Intaqe changes that.

The burden

Case processing is a tax on every clinical program.

Adverse-event volumes climb 10–15% a year while safety budgets stay flat. For biotech and pharma, book-in, triage, entry, medical review and QC — all by hand, on every case and every follow-up — consume the majority of the PV budget and run against a non-negotiable reporting clock.

40–80%
of the PV budget goes to case processing
10–15%
annual growth in case volume
$350–$500
to process one serious case by hand
7 days
to report a fatal case — the clock never stops
The case journey

Four manual stages. One engine. Under a minute.

Book-in, triage, case entry and Initial Medical Review take a team of people and days. Intaqe does all four against your preloaded RSI — then a simple QC by your CRO or sponsor.

Traditional intake — 5 people · days$350–$500 per case
Person 1
Book-in
Person 1–2
Triage
Person 2
Case entry
Physician
Initial Medical Review
Person 3
Full QC
SAE worksheet
EDC extract
Study RSI
IntaqeONE ENGINE
UNDER 1 MINUTE
Book-in
received & logged
Triage
valid & serious?
Case entry
E2B(R3) fields
Initial Medical Review
vs preloaded RSI
↓  QC-ready E2B(R3) case, every field evidence-linked
Human in the loop
Simple QC of E2B fields
CRO or Sponsor · 1 sign-off
Delivered
Safety database
Argus / Veeva

No book-in queue. No manual entry. No full QC. Just a simple QC of the E2B fields — in under a minute.

The engine

Generative AI, engineered for regulated safety data.

Large language models read the source. Small, specialized models extract, code and assess. A deterministic regulatory layer enforces E2B(R3), MedDRA/WHODrug and the seriousness & RSI rules. Paired with our proprietary data-ingestion system, that cuts case-processing cost 60–70% — with regulatory-grade, schema-valid output.

Ingest
Proprietary data ingestion
SAE worksheet · EDC · email · scan
Translate
In-model translation
any language · original retained
Read · LLM
Large language model
reads & understands any source
Extract · SLM
Small language models
extraction · coding · expectedness
Enforce
Deterministic regulatory layer
E2B(R3) · MedDRA/WHODrug · RSI rules
Verify
Simple QC
CRO or Sponsor · 1 sign-off
60–70% lower case-processing cost — with regulatory-grade, schema-valid E2B(R3) output, human-verified.
Generative models read and interpret; deterministic logic enforces compliance; a qualified human signs off. Cost figures are pre-validation targets.
No clock lost to translation

Any language in — the clock runs on review, not translation.

Source documents arrive in dozens of languages. Traditional intake ships them to a translation vendor first — days gone before processing even starts, against a 7- or 15-day clock. Intaqe translates in-model the moment a case lands, keeps the original for the record, and processes immediately.

Source · any language
日本語DeutschFrançais中文Español
In-model translation
Translated on arrival. Original retained for the record — nothing leaves for a third-party queue.
Processed immediately
0 days spent outside the clock
The 7-/15-day clock is spent on medical review and QC — not waiting on a translation vendor.
Not a book-in tool

A book-in tool logs the case. Intaqe finishes it.

Traditional intake software captures the document and routes it — every downstream task still lands on a person. Intaqe does the work and hands your CRO or sponsor a finished, QC-ready case to verify.

Traditional book-in tool

Captures & routes

01Receive documentauto
02Log & queuemanual
03Route to a personmanual
04Human does entry, coding, review & QCmanual
The work is still yours.
Intaqe

Does the work

01Read & extract any sourceAI
02Code & assess seriousnessAI
03Initial Medical Review vs RSIAI
04QC-ready E2B(R3) → simple QC (CRO or Sponsor)verify
You verify. We do the rest.
The value

Biotechs save millions a year on manual case processing.

$450K
saved per year at 1,500 cases — versus processing them by hand.
2501.5k3k
Assumes ~$300 saved per case (manual $350–$500 → Intaqe). Illustrative; pre-validation.
$300K
at 1,000 cases / year
$600K
at 2,000 cases / year
$900K
at 3,000 cases / year

Industry-reported per-case processing ranges; per-case saving is an illustrative target pending validation.

Per case

From $350–$500 by hand to a fraction with Intaqe.

−0%
lower cost per case — and the saving repeats on every case and every follow-up version.

Cost to process one serious case

Traditional manual intake$350–$500
With Intaqe$120–$175
60–70% lowerper case, every case
Industry-reported ranges; figures illustrative, reduction is a target pending validation.
Built in

Initial Medical Review — against your preloaded RSI.

Load the study Reference Safety Information once. Intaqe makes a medical-grade first call on reportability on every case, with the evidence shown — so your CRO or sponsor simply confirms, at a fraction of the cost.

INITIAL MEDICAL REVIEW · PRELOADED RSI · < 1 MIN
1
RSI preloaded
Loaded once, per protocol.
2
Every event assessed
Checked against the RSI, per product — with the reference line quoted.
3
Reportability proposed
Seriousness, expectedness and the 7-/15-day clock — informational, with evidence.
4
CRO or Sponsor confirms
A simple QC sign-off by your CRO or sponsor. The binding decision stays with them.
The output

A QC-ready E2B(R3) case — fields verified, evidence linked.

Every field arrives populated, grounded to its source, and confidence-scored. Your CRO or sponsor reviews the E2B fields and signs off — a simple QC, not a re-keying.

intaqe.ai/case/SAE-2041 · review
E2B(R3) field reviewQC-READY · AWAITING SIGN-OFF
Patient (D)Male · 68y · 71 kgverified
Suspect drug 1 (G)CVL-231 · possibly relatedverified
Suspect drug 2 (G)Investigational ADC · probably relatedverified
Reaction (E) · PTFebrile neutropenia + Septic shockverified
SeriousnessDeath · Life-threatening · Hospitalizationverified
ExpectednessSeptic shock — unexpected (specificity)review
Reporting clock7-day · informationalreview
Architecture

How a case moves through Intaqe.

A regulated pipeline: every stage logged, every artifact versioned, every action attributable — on a foundation your IT and quality teams already trust.

01IngestAPI · email · SFTP · safety-DB
02Pre-processOCR · translation · layout
03AI extractionLLM · SLM · coding
04Compliance & QA gateschema · confidence · rules
05Review portalhuman in the loop · e-sign
06E2B(R3) outArgus · Veeva · ArisGlobal
Foundation Okta SSORBACAudit trail · 21 CFR Part 11EncryptionTenant isolationModel & prompt versioning
Built for inspection

An enterprise portal your quality and IT teams sign off on.

GxP-aligned, validated, and access-controlled from day one — so adopting Intaqe doesn't open a compliance gap.

Okta & SSO

Single sign-on via Okta, SAML or OIDC. SCIM provisioning, MFA and your identity policies — no separate logins to manage.

21 CFR Part 11

Immutable audit trails and electronic signatures on every action, attributable to a named user.

GxP validation

GAMP 5 / CSA-aligned with IQ/OQ/PQ evidence for your CSV file. GCP and GVP Module VI aligned.

Data protection

Encryption in transit and at rest, regional data residency (GDPR), tenant isolation, and zero-retention LLM terms — your data never trains a model.

Role-based access

Least-privilege RBAC with full user and action traceability across the portal.

Versioned & reproducible

Every case stamped with model, prompt and dictionary version — reproducible for inspection.

Validation and compliance posture is established during onboarding; specific certifications are confirmed at implementation.

Every field grounded to its source · 21 CFR Part 11 · GVP-aligned · Human-verified, every time

See it on your own documents.

A 30-minute walkthrough with your (de-identified) worksheet or EDC export — processed live.

Request a demo